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A Lethal Inheritance

A Mother Uncovers the Science Behind Three Generations of Mental Illness.

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1 of 1 copy available
1 of 1 copy available
Every family has secrets; only some secrets are lethal. In Victoria Costello's family mental illness had been given many names over at least four generations until this inherited conspiracy of silence finally endangered the youngest members of the family, her children.
In this riveting story—part memoir, detective story, and scientific investigation—the author recounts how the mental unraveling of her seventeen-year-old son Alex compelled her to look back into family history for clues to his condition. Eventually she tied Alex's descent into hallucinations and months of shoeless wandering on the streets of Los Angeles to his great grandfather's suicide on a New York City railroad track in 1913.
But this insight brought no quick relief. Within two years of Alex's diagnosis of paranoid schizophrenia, both she and her youngest son succumbed to two different mental disorders: major depression and anxiety disorder.
Costello depicts her struggle to get the best possible mental health care for her sons and herself, treatment that ultimately brings each of them to full recovery. In the process, she discovers new science that explains how clusters of mental illness traverse family generations. Artfully weaving the scientific into the personal, Costello takes a journey to the far reaches of neuroscience and reports back on the startling findings it is yielding about the complex interplay between genes and environment that drives mental illness, and what it now tells us about how parents can trump a lethal inheritance.
She shares the results of long-term U.K. and European family studies identifying the earliest signs of mental illnesses that can be passed on from grandparents to parents and grandchildren. She tracks ongoing clinical trials to reverse the courses of these diseases through early intervention with the latest evidence-based treatments and offers brain-healthy choices individuals and families can make to prevent mental illness—freeing future generations to live healthier, happier lives.
From the Trade Paperback edition.
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    • Publisher's Weekly

      October 24, 2011
      A science journalist and mental health advocate in San Francisco, Costello offers both an affecting chronicle of her family’s mental illness and a useful guide to detection and prevention. Both of her sons suffered for years and were occasionally hospitalized—the eldest, Alex, was finally diagnosed with paranoid schizophrenia at age 18 in 1998; his younger brother by six years, Sammy, battled anxiety and depression. While signs of antisocial behavior had been prevalent for years, Alex’s illness exploded at age 14 (not unusual during the maturation process of adolescence), while Sammy, too, hit middle school “like a wind-up toy whose batteries simply gave out.” What Costello had to face was what she calls “connecting the dots” from her children’s mental illness to that of several generations of family members, such as her father’s alcoholism and depression, her sister’s death from a drug overdose, and her own depression and abuse of alcohol. Attempting to diagnose children for mental disorders takes into account this predisposition and family history (Costello cites one study of the susceptibility of the Irish to mental illness), useful for early detection and treatment; moreover, recognizing and avoiding environmental factors for at-risk kids such as chaos at home (i.e., divorce), bullying, and drug abuse can actually prevent the onset of mental illness. In the end, Costello presents a book of vigorous personal and factual research.

    • Booklist

      December 1, 2011
      Science journalist Costello's educative memoir gives poignant testimony to the fact that not only do we stand on the shoulders of those who came before us; we carry their burdens as well. At the point where it was almost too late to intervene in her eldest son's mental deterioration, Costello embarked on a journey backward in time that moved her and both of her sons forward into a brighter future. While admitting Costello's son to a psychiatric ward, the admissions counselor inspired her to examine the skeletons in her family's closet. Therein Costello discovered generations of psychiatric issues that, upon investigation, increased her and her sons' risk for mental illness. Had these problems not been kept secretas too many families doshe could have avoided present-day heartbreaking circumstances. The story Costello shares is a twofer. It is a cautionary tale about the price families pay for keeping mental illness secret. It is also a road map for identifying risk factors for and recognizing early signs of psychiatric issues, the better to preempt advanced disease.(Reprinted with permission of Booklist, copyright 2011, American Library Association.)

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  • English

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